๐งซ Scientists Revive a Last-Resort Antibiotic by Targeting One Key Bacterial Enzyme
Vancomycin has been a last-resort antibiotic for decades, but dangerous bacteria evolved to resist it โ until now. Scripps Research scientists found that disabling an enzyme called SagA in vancomycin-resistant Enterococcus makes the bacteria dramatically vulnerable to the drug again. The study, published in Nature Communications, targets an enzyme found across many resistant strains, making it a potentially broad fix. Could this approach help resurrect other antibiotics that superbugs have defeated?